| 基 本 信 息 | ||
| CAS编码 | 67-72-1 | |
| Development Codes | ||
| IUPAC名称 | 1,1,1,2,2,2-hexachloroethane | |
| 英文通用名称 | Hexachloroethane | |
| 中文通用名称 | 六氯乙烷 [进入食品百科查看-- 六氯乙烷 的信息] | |
| 英文商品名称 | ||
| 中文商品名称 | ||
| 英文化学名称 | Hexachloroethane | |
| 中文化学名称 | 六氯乙烷 | |
| 理 化 性 质 | ||
| 分子式 | C2Cl6 | |
| 结构式 |
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| 分子量 | 236.72 | |
| 性状描述 | 结晶体，带樟脑味。mp786-787℃，密度2.09。不溶于水；可溶于醇、苯、氯仿、醚和油类。 | |
| 毒 理 学 性 质 | ||
| LD50/LC50 | 兔皮下注射致死最低量，4000mg/kg，狗静脉注射LD50,325mg/kg。人口服致死最低量，50mg/kg。 ** 急性毒性数据 ** 测试类型 : LD50 - Lethal dose, 50 percent kill 接触途径 : Oral 测试物种 : Rodent - rat 剂量/时间 : 4460 mg/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value 测试类型 : LCLo - Lowest published lethal concentration 接触途径 : Inhalation 测试物种 : Rodent - rat 剂量/时间 : 5900 ppm/8H 毒性作用 : Behavioral - muscle weakness 测试类型 : LDLo - Lowest published lethal dose 接触途径 : Intraperitoneal 测试物种 : Rodent - rat 剂量/时间 : 2900 mg/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value 测试类型 : LD50 - Lethal dose, 50 percent kill 接触途径 : Intraperitoneal 测试物种 : Rodent - mouse 剂量/时间 : 4500 mg/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value 测试类型 : LDLo - Lowest published lethal dose 接触途径 : Intravenous 测试物种 : Mammal - dog 剂量/时间 : 325 mg/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value 测试类型 : LD - Lethal dose 接触途径 : Oral 测试物种 : Rodent - rabbit 剂量/时间 : >1 gm/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value 测试类型 : LD50 - Lethal dose, 50 percent kill 接触途径 : Administration onto the skin 测试物种 : Rodent - rabbit 剂量/时间 : 32 gm/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value 测试类型 : LDLo - Lowest published lethal dose 接触途径 : Subcutaneous 测试物种 : Rodent - rabbit 剂量/时间 : 4 gm/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value 测试类型 : LD50 - Lethal dose, 50 percent kill 接触途径 : Oral 测试物种 : Rodent - guinea pig 剂量/时间 : 4970 mg/kg 毒性作用 : Details of toxic effects not reported other than lethal dose value ** OTHER MULTIPLE DOSE TOXICITY DATA ** 测试类型 : TDLo - Lowest published toxic dose 接触途径 : Oral 测试物种 : Rodent - rat 剂量/时间 : 6944 mg/kg/16W-C 毒性作用 : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight 测试类型 : TDLo - Lowest published toxic dose 接触途径 : Oral 测试物种 : Rodent - rat 剂量/时间 : 9 gm/kg/16D-I 毒性作用 : Related to Chronic Data - death 测试类型 : TDLo - Lowest published toxic dose 接触途径 : Oral 测试物种 : Rodent - rat 剂量/时间 : 48750 mg/kg/13W-I 毒性作用 : Brain and Coverings - changes in brain weight Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight 测试类型 : TCLo - Lowest published toxic concentration 接触途径 : Inhalation 测试物种 : Rodent - rat 剂量/时间 : 260 ppm/6H/6W-I 毒性作用 : Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight Related to Chronic Data - changes in testicular weight 测试类型 : TDLo - Lowest published toxic dose 接触途径 : Oral 测试物种 : Rodent - rabbit 剂量/时间 : 12 gm/kg/12D-C 毒性作用 : Liver - other changes Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain 测试类型 : TCLo - Lowest published toxic concentration 接触途径 : Inhalation 测试物种 : Rodent - guinea pig 剂量/时间 : 260 ppm/6H/6W-I 毒性作用 : Liver - changes in liver weight Related to Chronic Data - death ** TUMORIGENIC DATA ** 测试类型 : TDLo - Lowest published toxic dose 接触途径 : Oral 测试物种 : Rodent - rat 剂量/时间 : 10300 mg/kg/2Y-C 毒性作用 : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors 测试类型 : TDLo - Lowest published toxic dose 接触途径 : Oral 测试物种 : Rodent - mouse 剂量/时间 : 230 gm/kg/78W-I 毒性作用 : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors 测试类型 : TD - Toxic dose (other than lowest) 接触途径 : Oral 测试物种 : Rodent - mouse 剂量/时间 : 460 gm/kg/78W-I 毒性作用 : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors ** REPRODUCTIVE DATA ** 测试类型 : TDLo - Lowest published toxic dose 接触途径 : Oral 测试物种 : Rodent - rat DOSE : 5500 mg/kg SEX/DURATION : female 6-16 day(s) after conception 毒性作用 : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility ** 致突变数据 ** 测试类型 : Mutation test systems - not otherwise specified 接触途径 : Oral TEST SYSTEM : Rodent - mouse 剂量/时间 : 1 gm/kg 测试类型 : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary 剂量/时间 : 330 mg/L *** 综述 *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 9.7 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,467,1979 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,467,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40(3),A46,1979 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 ppm (10 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,124,1971 OSHA PEL (Gen Indu):8H TWA 1 ppm (10 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 ppm (10 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 ppm (10 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 ppm (10 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (100 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (9.7 mg/m3) JAN 1993 OEL-DENMARK:TWA 1 ppm (10 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 1 ppm (10 mg/m3);STEL 3 ppm (30 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (100 mg/m3) JAN 1993 OEL-GERMANY:TWA 1 ppm (10 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (10 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 1 ppm (10 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (10 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (50 mg/m3) (vapor) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH 标准发展和监测数据 *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HEXACHLOROETHANE-air:8H CA TWA 1 ppm NIOSH 职业性接触鉴定数据 : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 17385 No. of Facilities: 219 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 1488 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 17385 No. of Facilities: 170 (estimated) No. of Industries: 12 No. of Occupations: 23 No. of Employees: 8516 (estimated) No. of Female Employees: 576 (estimated) |
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| NOEL | ||
| NOAEL | ||
| LOAEL | ||
| ADI | ||
| BMD | ||
| PTWI | ||
| PTDI | ||
| RfD | ||
| MTD | ||
| Acute RfD | ||
| 是否致癌物 | × | |
| 是否基因致癌物 | × | |
| 其他毒理学性质 | 无 | |
| 应 用 情 况 | ||
| 国内应用情况 | 国内登记或注册 | × |
| 国内生产 | × | |
| 国外进口 | × | |
| 国外应用情况 | 无 | |
| 其 他 信 息 | ||
| 类别 | 熏蒸剂和家畜驱虫剂 | |
| 作用 | 熏蒸剂和家畜驱虫剂。可防治家禽肝和胃的肝蛭。 | |
| 作用特点 | 无 | |
| 代谢情况 | 无 | |
| 日本肯定列表 | ||
| 相关标准 | ||
| 相关资料 | ||
| 相关讨论 | ||
| 相关限量 | ||
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| 备注 | 无 | |
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