| 基 本 信 息 | ||
| CAS编码 | 107-02-8 | |
| Development Codes | ||
| IUPAC名称 | prop-2-enal; acrylaldehyde | |
| 英文通用名称 | acrolein | |
| 中文通用名称 | 丙烯醛 [进入食品百科查看-- 丙烯醛 的信息] | |
| 英文商品名称 | ||
| 中文商品名称 | ||
| 英文化学名称 | 2-propenal | |
| 中文化学名称 | ||
| 理 化 性 质 | ||
| 分子式 | C3H4O | |
| 结构式 |
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| 分子量 | 56.1 | |
| 性状描述 | Composition:Tech. is 92-97%.Form:Colourless mobile liquid with a pungent odour. M.p.: -87 ℃ B.p.: 52.5 ℃ V.p.: 59 kPa (38 ℃) Henry: 7.9 (calc.), 19.5 (measured) (both in kPa m3 mol-1)S.g./density: 0.841 (4 ℃-20 ℃) Solubility: In water 208 g/kg (20 ℃). Miscible with lower alcohols, ketones, benzene, diethyl ether and other common organic solvents.Stability: Stable ≤80 ℃; highly reactive chemically. May polymerise if exposed to light (stabiliser, e.g. hydroquinone). Polymerises slowly on storage and violently in the presence of concentrated acids. Must be stored in the dark, under nitrogen. Hydrolysis DT50 3.5 d (pH 5), 1.5 d (pH 7), 4 h (pH 10). Transported in oxygen-free atmospheres in the presence of polymerisation inhibitor. F.p.: Closed cup <-17.8 ℃ | |
| 毒 理 学 性 质 | ||
| LD50/LC50 | Oral: Acute oral LD50 for rats 29, male mice 13.9, female mice 17.7 mg/kg.Skin and eye Acute percutaneous LD50: for rabbits 231 mg/kg. Skin irritant; lachrymatory effect and irritant action on respiratory organs at <1 mg/kg. Inhalation: (4 h) for rats 8.3 mg/l air.Birds: Acute oral LD50 for bobwhite quail 19, mallard ducks 30.2 mg/kg (studies were for tech. material; maximum rate in use is 15 mg/l water, so potential exposure is substantially reduced).Fish: Highly toxic to fish. Concentrations of 1-5 mg/l are deadly. LC50 (24 h) for rainbow trout 0.15, bluegill sunfish 0.079, shiners 0.04, and mosquito fish 0.39 mg/l.Bees: Daphnia: Algae: EC50 (5 d) for Selenastrum capricornutum 0.050, Anabaena flos-aquae 0.042, Navicula pelliculosa 0.07, Skeletonema costatum 0.03 mg/l.Worms: Other aquatic spp.: LC50 (48 h) for shrimps 0.10, oysters 0.46 mg/l. EC50 (14 d) for Lemna gibba 0.07 mg/l. | |
| NOEL | (90 d) for rats 5 mg/kg b.w. daily. Administration of 200 mg acrolein/l water to rats for 90 d causes no ill-effects. No reproductive toxicity in 2-generation feeding study in rats at 7.2 mg/kg daily. No teratogenic effect in rabbits at levels causing maternal toxicity (maximum dose 2 mg/kg daily). | |
| NOAEL | ||
| LOAEL | ||
| ADI | ||
| BMD | ||
| PTWI | ||
| PTDI | ||
| RfD | ||
| MTD | ||
| Acute RfD | ||
| 是否致癌物 | × | |
| 是否基因致癌物 | × | |
| 其他毒理学性质 | Toxicity class EPA(formulation): I | |
| 应 用 情 况 | ||
| 国内应用情况 | 国内登记或注册 | × |
| 国内生产 | × | |
| 国外进口 | × | |
| 国外应用情况 | 无 | |
| 其 他 信 息 | ||
| 类别 | Herbicide | |
| 作用 | Biochemistry: Reaction with the sulfhydryl groups of enzymes. Mode of action: Contact herbicide which breaks down cell walls. Uses: An aquatic herbicide, injected below the water surface (1-15 mg/l), to control submersed aquatic weeds and algae in irrigation canals and drainage ditches. Little effect on emergent weeds at recommended rates. Floating weeds such as Pistia, Eichornia and Jussiaea spp. controlled only if concentration is maintained for extended period. Phytotoxicity: Compatibility: It is not customary to mix with other preparations. | |
| 作用特点 | 无 | |
| 代谢情况 | Animals: In goat and hen, no acrolein was detected in tissues or excreta, or in goat milk or hen eggs following administration of high doses. All residues identified are natural products. Data on naturally occurring metabolites found in aquatic species are also available. Plants: Following high application rates to lettuce, no acrolein was detected 1 day following last application. At harvest, 3 highly polar conjugates (representing in total <0.5 ppm) were detected. Soil/environment: DT50 in water 150 h (pH 5), 120-180 h (pH 7), 5-40 h (pH 9). Acrolein is metabolised easily in soil, being mineralised to CO2. Metabolic pathways involving oxidation, reduction and hydration have been proposed. | |
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